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Raghuram, N.
- Reactive Nitrogen Assessment in South Asia
Abstract Views :302 |
PDF Views:91
Authors
Affiliations
1 South Asian Nitrogen Centre and Indian Nitrogen Group, F-4, NASC Complex, DPS Marg, New Delhi 110 012, IN
1 South Asian Nitrogen Centre and Indian Nitrogen Group, F-4, NASC Complex, DPS Marg, New Delhi 110 012, IN
Source
Current Science, Vol 111, No 5 (2016), Pagination: 782-783Abstract
The nitrogen (N) cycle is anthropogenically the most disturbed nutrient cycle having adverse impacts on majority of ecological compartments and resultant ecosystem services. Such perturbations adversely impact food security, energy, industry, human health, biodiversity, environment and climate change. Reactive nitrogen (Nr) includes inorganic (from both sides of the redox range, including NH3, NH4+, NOx, N2O, NO2-, NO3-) and organic (urea, amines) variants that readily interact in the environment.- Development and Evaluation of Propranolol Hydrochloride Floating Matrix Tablets Using Combination of Natural and Synthetic Polymers
Abstract Views :179 |
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Authors
Affiliations
1 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur (Dt), Andhra Pradesh- 522101, IN
2 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur (Dt), Andhra Pradesh-. 522101, IN
1 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur (Dt), Andhra Pradesh- 522101, IN
2 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur (Dt), Andhra Pradesh-. 522101, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 3, No 6 (2011), Pagination: 276-280Abstract
In the present investigation, an attempt was made to formulate Propranolol hydrochloride sustained release floating matrix tablets using dried Hibiscus rosa-sinensis leaves mucilage and to study its release retardant activity in combination with hydroxypropyl methyl cellulose grades. Different floating matrix tablets of Propranolol HCl were formulated. The floating matrix tablets found to have better uniformity of weight, hardness, friability and drug content. The swelling behavior, release rate characteristics and the invitro dissolution study proved that the dried Hibiscus rosa-sinensis leaves mucilage can be used as a matrix forming material for preparing sustained release floating matrix tablets. The release rate followed zero-order release kinetics and the data was fitted in the Peppas plots. The exponential coefficient from the Peppas plots was found to be in between 0.55 to 0.64, indicating non-fickian mechanism of drug release.Keywords
Hibiscus rosa-sinensis Leaves Mucilage, Gastric Residence Time, Propranolol Hydrochloride, Floating Drug Delivery, Hydroxypropyl Methyl Cellulose.- An Overview on Various Approaches for Gastroretentive Drug Delivery Systems
Abstract Views :189 |
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Authors
Affiliations
1 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur (Dt), Andhra Pradesh-522101, IN
1 Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Guntur (Dt), Andhra Pradesh-522101, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 3, No 4 (2011), Pagination: 107-116Abstract
In recent years scientific and technological advancements have been made in the research and development of controlled release oral drug delivery systems by overcoming physiological adversities like short gastric residence times and unpredictable gastric emptying times. To overcome these limitations, gastroretentive drug delivery systems (GRDDS), have been developed to increase gastric residence of drug delivery systems in the upper part of the gastrointestinal tract. GRDDS can improve the controlled delivery of drugs that have an absorption window by continuously releasing the drug for a prolonged period of time before it reaches its absorption site, thus ensuring its optimal bioavailability. This article provides the classification of gastroretentive systems, formulation considerations for developing gastroretentive systems, factors affecting gastroretentive systems such as density, size, shape, single or multiple unit formulations, fed or unfed state, nature of meal, caloric content, frequency of feed, gender, age, posture, concomitant drug administration and biological factors limelight this article.Keywords
Gastroretentive Drug Delivery Systems (GRDDS), Floating Systems, Bioadhesive Systems, Hydrodynamically Balanced Systems (HBS), Gastrointestinal Tract (GIT).- A Review on Colonic Drug Delivery System
Abstract Views :338 |
PDF Views:0
Authors
Affiliations
1 Bapatla College of Pharmacy, Bapatla, IN
2 Sri Padamavati Mahila University, Tirupati, IN
1 Bapatla College of Pharmacy, Bapatla, IN
2 Sri Padamavati Mahila University, Tirupati, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 3, No 4 (2011), Pagination: 122-129Abstract
Colon specific drug delivery has gained a much importance for the delivery of drugs to treat the both local and systemic diseases. Local diseases include Chron's disease, ulcerative colitis, and colorectal cancer. Number of other serious disorders like nocturnal asthma, arthritis and angina can also be cured by these techniques. Colonic delivery is a good candidature for delivery of proteins peptides and vaccines where the enzymatic degradation and the hydrolysis of proteins can be minimized and increases the systemic bioavailability. A drug should be protected from the absorption and the upper GI environment to achieve the successful colonic drug delivery. The colon specific delivery of drugs to the target receptor sites has the advantage to reduce the side effects and improves the therapeutic response. Colon specific drug delivery are being developed by taking advantage of the luminal PH conditions and the presence of microbial enzymes such as azoreductase, pectinase, dextranase…etc. This review mainly reveals on the various concepts and approaches include Prodrug, PH and time dependent systems and microbially triggered systems used in the development of colon specific drug delivery. This also focuses on the novel approaches namely Pressure controlled colonic delivery, osmotic controlled drug delivery and CODESTM. In vitro and in vivo evaluation parameters has been discussed here.Keywords
CDDS (Colon Drug Delivery System), Prodrug Approaches, PH Dependent Systems, Microbially Activated Systems, Novel Approaches.- Yash Pal Abrol (1935–2020)
Abstract Views :191 |
PDF Views:82
Authors
Affiliations
1 Trustees, Sustainable India Trust and Office Bearers, Society for Conservation of Nature, New Delhi, IN
1 Trustees, Sustainable India Trust and Office Bearers, Society for Conservation of Nature, New Delhi, IN
Source
Current Science, Vol 119, No 3 (2020), Pagination: 571-572Abstract
No Abstract.Keywords
No Keywords.- Two South Asians from UNEP Shared the First Y. P. Abrol Memorial Award
Abstract Views :196 |
PDF Views:98
Authors
Affiliations
1 Sustainable India Trust and Society for Conservation of Nature; School of Biotechnology, GGS Indraprastha University, New Delhi 110 078, IN
1 Sustainable India Trust and Society for Conservation of Nature; School of Biotechnology, GGS Indraprastha University, New Delhi 110 078, IN
Source
Current Science, Vol 120, No 12 (2021), Pagination: 1810-1810Abstract
No Abstract.Keywords
No Keywords.References
- Raghuram, N., Adhya, T. K. and Pathak, H., Curr. Sci., 2020, 119, 571.
- Abrol, Y. P. et al. (eds), The Indian Nitrogen Assessment: Sources of Reactive Nitrogen, Environmental and Climate Effects, Management Options, and Policies, Elsevier, UK, 2017, pp. 538; ISBN: 978-0-12-811836-8.
- United Nations Environment Programme. Resolution adopted by the United Nations Environment Assembly on 15 March 2019: sustainable nitrogen management. United Nations Environment Assembly of the United Nations Environment Programme, fourth session, Nairobi, 11–15 March 2019; UNEP/EA.4/L.16; https://wedocs.unep.org/bitstream/handle/20.500.11822/ 28478/English.pdf?sequence=3&isAllowed=y
- Adhya, T. K., Pathak, H. K., Raghuram, N. and Abrol, Y. P., Curr. Sci., 2016, 111(5), 782–783.
- Raghuram, N., Sutton, M. A., Jeffery, R., Ramachandran, R. and Adhya, T. K., One Earth, 2021, 4(1), 22–27; https://doi.org/ 10.1016/j.oneear.2020.12.017